Epidermal Melanin Units Melanocyte-Keratinocyte Interactions
نویسندگان
چکیده
منابع مشابه
Melanocyte-keratinocyte interactions in vivo: the fate of melanosomes.
Studies on pigment donation in tissue culture (1-5) indicate that melanosome transfer is a cytophagic process during which a portion of a melanocyte dendrite is pinched off by the epidermal cell so that melanosomes and melanocyte cytoplasm are incorporated into the keratinocyte. At the ultrastructural level, one would ex-rect to see, at this stage, a cluster of melanosomes embedded in a cytopla...
متن کاملRole of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species
We have recently reported a potential alternative tumor suppressor function for p16 relating to its capacity to regulate oxidative stress and observed that oxidative dysregulation in p16-depleted cells was most profound in melanocytes, compared to keratinocytes or fibroblasts. Moreover, in the absence of p16 depletion or exogenous oxidative insult, melanocytes exhibited significantly higher bas...
متن کاملUltraviolet B, melanin and mitochondrial DNA: Photo-damage in human epidermal keratinocytes and melanocytes modulated by alpha-melanocyte-stimulating hormone
Alpha-melanocyte-stimulating hormone (alpha-MSH) increases melanogenesis and protects from UV-induced DNA damage. However, its effect on mitochondrial DNA (mtDNA) damage is unknown. We have addressed this issue in a pilot study using human epidermal keratinocytes and melanocytes incubated with alpha-MSH and irradiated with UVB. Real-time touchdown PCR was used to quantify total and deleted mtDN...
متن کاملKeratinocyte apoptosis in epidermal development and disease.
Keratinocyte (KC) apoptosis plays a critical role in regulating epidermal development and restraining carcinogenesis. Apoptosis balances proliferation to maintain epidermal thickness, contributes to stratum corneum formation and may eliminate pre-malignant cells. Apart from the normal developmental program, KC apoptosis can be triggered by UV light and other stimuli. Dysfunctional apoptosis occ...
متن کاملEpiprofin orchestrates epidermal keratinocyte proliferation and differentiation.
The basal layer of the epidermis contains stem cells and transit amplifying cells that rapidly proliferate and differentiate further into the upper layers of the epidermis. A number of molecules have been identified as regulators of this process, including p63 (also known as tumor protein 63) and Notch1. However, little is known about the mechanisms that regulate the transitions from stem cell ...
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ژورنال
عنوان ژورنال: American Zoologist
سال: 1972
ISSN: 0003-1569
DOI: 10.1093/icb/12.1.35